The importance of cyclic adenosine monophosphate (cAMP) in cellular responses to extracellular signals is well established.Many years after discovery, our understanding of the intricacy of cAMP signaling has improved dramatically.Multiple layers of regulation exist to ensure the specificity of cellular cAMP signaling.Hence, disturbances in cAMP hom
Abstract Background Critically ill patients receiving invasive ventilation are at risk of sputum retention.Mechanical insufflation-exsufflation (MI-E) is a technique used to mobilise sputum and optimise airway clearance.Recently, interest has increased in the use of mechanical insufflation-exsufflation for invasively ventilated critically ill adult
Abstract An electroweak multiplet stable due to a new global symmetry is a simple and well-motivated candidate for thermal dark matter.We study how direct searches at a future linear collider, such as the proposed CLIC, can constrain scalar and fermion triplets, quintets and septets, as well as a fermion doublet.The phenomenology is highly sensitiv